| Group | Club/Team Name | Team ID | Head Coach |
| D21 | Cainhoy Athletic Soccer Club CASC 11 Sharks |
03006-001AB2U-2310 | Gustavo Zampieri Silva |
| D22 | Cainhoy Athletic Soccer Club CASC 11 Thunder |
03006-001AB2U-2308 | Rhys Mallinger |
| D23 | Cainhoy Athletic Soccer Club CASC 11 Titans |
03006-001AB2U-2311 | Evan Luck |
| D24 | Charleston Soccer Club LLC CSC 11 Boys Yellow North II |
03034-001AB2U-0032 | Burke Hazard |
| D25 | James Island Youth SC JIYSC 2011 Boys Red Garrett |
03001-001AB2U-1149 | Stewart Garrett |
| D26 | James Island Youth SC JIYSC 2011 Boys Red Jones |
03001-001AB2U-1148 | Brian Jones |
| D27 | Mt. Pleasant SC - 01 MPRD Lightning U12B |
03007-001RB2U-0015 | Robert Decker |
| D28 | South Carolina Surf Soccer Club SC Surf MP 11 Blue |
03008-001AB2U-5572 | Stephen Sweeney |