| Group | Club/Team Name | Team ID | Head Coach |
| D21 | Cainhoy Athletic Soccer Club CASC 11 Riptides Blue |
03006-001AG2U-2293 | Steven Spengler |
| D22 | Cainhoy Athletic Soccer Club CASC 11 Riptides Grey |
03006-001AG2U-2334 | Gabriela Acosta |
| D23 | Charleston City FC CCFC U12 Girls |
03014-001RG2U-0005 | Alison Davis |
| D24 | Coast FA - 01 Coast 11G Red |
03018-001AG2U-4668 | John Zimmer |
| D25 | James Island Youth SC JIYSC 2011 Girls Black Hedley |
03001-001AG2U-1137 | Ryan Hedley |
| D26 | James Island Youth SC JIYSC 2011 Girls Black Ryan |
03001-001AG2U-1138 | Ryan Hedley |
| D27 | Mt. Pleasant SC - 01 MPRD Springers U12G |
03007-001RG2U-0008 | Kevin McNamara |
| D28 | South Carolina Surf Soccer Club SC Surf NA 11 Blue |
03008-001AG2U-5588 | Megan McCue-Jones |
| D29 | Tormenta FC Academy - 01 TFC 11G Magenta |
03035-001AG2U-0017 | Kian Brownlee |
| D210 | Daniel Island SA DISA Breakers |
03030-0012G3U-0014 | Erik Cobb |